منابع مشابه
Antigenic Streptococcal Hemolysin
1. Normal serum, used in cultures for preparation of the streptolysin, modifies the properties of the streptolysin, causing delayed hemolysis, increased filterability, resistance to oxidation or reduction, and absence of antigenicity. 1. Streptolysin prepared without serum is an active antigen. 3. Similar temperatures are required to destroy the antigenic activity of serum-free streptolysin and...
متن کاملANTIGENIC DOMAINS OF STREPTOCOCCAL Pep
M protein of the group A streptococcus is an elongated, alpha-helical coiledcoil molecule that extends from the bacterial cell surface as a flexible fibrillar structure (1, 2). It is a major virulence factor for the bacteria, by virtue of its property of impeding the phagocytosis of the organisms (3). >75 serologically distinct variants of the M protein have been recognized over the years and, ...
متن کاملSerologic Response to Streptococcal Hemolysin and Hyaluronidase in Streptococcal and Rheumatic Infection.
Although it has as yet not been possible to demonstrate the specific role of a causative organism in rheumatic fever, there has been considerable epidemiologic (1) and serologic (2) evidence of some relationship between the hemolytic streptococcus and this disease. Studies of both cellular and extracellular substances of the hemolytic streptococcus have with rare exceptions shown that groups of...
متن کاملThe Individual Antigenic Specificity of Antibodies to Streptococcal Carbohydrates
Although a single electrophoretically uniform antibody component with specificity for the group carbohydrate may comprise the bulk of the gamma-globulin in rabbits immunized with streptococcal vaccines, this is not always the case. Not infrequently, electrophoresis may reveal multiple antibody components. Nevertheless, it has been feasible by various preparative procedures to isolate from a sin...
متن کاملGroup B streptococcal beta-hemolysin induces nitric oxide production in murine macrophages.
Group B streptococcus (GBS) is the leading cause of sepsis in neonates. Nitric oxide (NO) release plays a role in the hypotension that characterizes septic shock. To examine the role of the GBS beta-hemolysin in NO production, the murine macrophage line RAW 264. 7 was exposed to a wild-type (WT) GBS isolate and to hyperhemolytic (HH) and nonhemolytic (NH) transposon mutants derived from that is...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1932
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.55.2.267